Nikolai N. KORPAN

Vienna, Austria

Short-time Cryo CV

• For the first time ever, in the 1980s, the definition of modern cryosurgery was introduced as well as the fundamental theoretical, experimental, and clinical studies began on modern cryosurgery in collaboration with engineers and designers.

• The first scientific presentation on the student scientific conference pointed on possibility of cryosurgery in oncology with published original abstract. Kyiv Medical Institute (since 1995 National Medical University), Kyiv, 03/1981.

• The first clinical experience using modern cryosurgery in abdominal surgery, especial pancreas and liver, with published original papers and dissertation.  Kyiv Medical Institute (since 1995 National Medical University), Kyiv, 03/1982-1985.

• Fundamental studies of biologic living substances: tissue and cells in animal provided a platform to understand the mechanisms of damage and the pathogenesis of frostbite during low temperature exposure.

• First introduction and performing of modern cryosurgery not only in palliative oncology but as a curative treatment option in surgical oncology.

• The first novel clinical experience using modern cryosurgery in palliative and curative oncolgy of liver, pancreas, breast, stomach, colon, anal, melanoma, skin, thyroid, lymph nodes, soft tissue (sarcoma) with published original papers. Vienna, Austria, since 1995 – at present.  

• Discoveries and Phenomena in living matter: “Cryosurgical Lunar Eclipse”, “Cryogenic Protein Denaturation”, “Anthill Provocation Stimulus Phenomenon”, “Cryosurgical Avascular Tumor”.

• New Terminology and Definition: Cryoscience, Cryogenic denaturation, Cryophenomen, Cryoapoptosis, Cryonecrosis, Cryogenic anti-angiogenesis, Nano-Cryoscience, Nano-Cryomedicine, Nano-Cryotreatment, Nano-Cryoablation, Nano-Cryoengineering, Nanocryogenic Technology, Nano-Cryoinstrument, Nano-Cryoprobe, Nano-Cryodevice, Nano-Cryoneedle, CryoVaccine, etc.

• For the first time, summarized a long-term follow-up clinical experience with cryosurgery for treatment of liver metastases. The data of this 10-year prospective, randomized clinical trial suggest that hepatic cryosurgery is effective in the treatment of resectable and non-resectable liver metastases (Ann Surg 1997;225:193-201).

• Both the formulation of a new concept concerning the clinical and technical requirements for modern cryosurgery and a new anticancer concept strategy including modern cryosurgery as a crucial and standard phase of each interventional surgical procedure and operation.

• Basic research for the interventional CryoDiagnostic in oncology using deep freezing of malignant tissue.

• The cryosurgical oncology could consists of the immobilisation tumor cryodiagnosis, nano-cryoscience, nano-cryomedicine, nano-cryosurgery, nano-cryoequipment, endoscopic cryosurgery, especially colon and stomach, navigation cryoscience and cryosurgery, anticancer cryovaccine, preventive cryomedicine in people with high-risk tumor, thyroid-cryosurgery, etc.

• Therefore, a new standard for oncological diagnosis and surgery has established a new level in the current and future of modern science and modern medicine.

• Original Papers and Abstracts - 248  (including the peer-reviewed Top-Journals: Annals of Surgery (USA), American J of Surgery, American J of Surgical Research, J of the American College of Surgeons, Technology in Cancer Research & Treatment (USA), etc.), including 10 monograhps on cryosurgery as author and editor.

• 1998 The Year Book of Surgery: Hepatic Cryosurgery for Liver Metastases: Long-term Follow-up, 346-48. Edward M. Copeland III (Editor-in-Chief), Mosby, 1998.

• National, European, and International Patents: 51.

• Lectures at the National, European and International Congresses – 172
  (Oral Presentation, 1979 – at present).

• Invited Lectures, Teaching, Seminars and Workshops at the International Universities and Scientific Research Institutions, including Karolinska Institutet, Stockholm, Sweden – 69.

• Scientific Documentary Films – 74, including personal Interviews and Documentary Films in the State TVs: Brussels, Belgium, 11/2002; ORF Channel, Modern Times, Republic of Austria, 01/2003; Coolangatta, Australia, 11/2008; Dubai, UEA 01/2009; Craiova University, State & Regional TV Romania, 02/2011; China State TV, 11/2011; St. Petersburg, Russian State TV, 06/2012; State TV China, 12/2012; State TV Tiraspol, Pridnestrovskaya Moldavskaya Respublika, 01/2013 & 06/2013.

• Scientific Documentary Slides - more than 10.470.

• Journal Citation Reports: Impact Factor – 30.671

• PubMed and Cumulated Index Medicus (1984 – at present) – 38, thereof PubMed - 22 and Cumulated Index Medicus - 16

• Korpan's Cited Scientific Articles in the World PubMed – 943

• Korpan's Scientific Citation in the International Scopus – 917

• Video YouTube - 21 (101.120 Visits, 18.09.2014)
  
  
  

• Last 33 years - thousands documented unique modern curative and palliative cryosurgical operations.

• Founder and Chairman, Vienna International Institute for Cryosurgery (since 01/2008 International Institute for Cryosurgery), Vienna, Austria, 01/1997.

• Foreign Editor, Journal of Low Temperature Medicine, Tokyo, Japan, since 11/2009.

• Co-Founder and Honorary Chairman, Asian Society of Cryosurgery, Guangzhou, China, 09/2010.

• 16^th ISC Congress President, Vienna, Austria, October-November 2011.

• ISC President, Headquarters in Vienna, Austria, since November 2^nd, 2011.

• Founder of the World Anticancer Movement "21^st Century: Humanity defeats Cancer" Vienna, Austria, April 2012.

• Chief Advisor of the Asian Society of Cryosurgery Guangzhou, China, May 2012 – at present.

• President of the World Anticancer Movement "21^st Century: Humanity defeats Cancer" Vienna, Austria, June 2012 – at present.

• Main Honours, Prizes & Awards:

• Ostrovski's State Scientific Research Prize: “Elaborate of the New Diagnostic Methods and Surgical Treatment of the Liver, Bile Ducts and Pancreas Diseases of Inflammatory and Oncological Etiology”, 384p.  USSR, Ukraine, Kyiv, 1986

• International Vienna Award for Physical Medicine: “Treatment of Surgical Patients with Postoperative Purulent Wounds - A New Physical Method”. Austria, Vienna, 1994

• Belgian Order “LE MERITE DE L’INVENTION”, Grade Chevalier (1500 participants from 54 countries). Brussels, Belgium, 2002

• ”Creative prize and Victoria Awards 2002” (Volkswagen AG), EXPO WORLD INVENTOR 2002 (1500 participants from 54 countries). Brussels, Belgium, 2002

• Gold Medal with Mention, BRUSSELS EUREKA 2002 (1500 participants from 54 countries). Brussels, Belgium, 2002

• American Gold Medal of Honour. American Biographical Institute of International Research, North Carolina, USA, 2002

• Outstanding Intellectuals of the 21^st Century Medal. International Biographical Centre, Cambridge, England, 2003

• Man of the Year 2003. American Biographical Institute of International Research, North Carolina, USA, 2003

• Highest Score of the Board of Directors of the International Society of Cryosurgery. Results of the International Society of Cryosurgery Questionnaire. London, U.K., 09/2003

• GOLD MEDAL for the best inventions. 32^nd International Exhibition of Inventions, New Techniques and Products (675 Exhibitors with 1.000 inventions from 42 countries and 5 continents). Geneva, Switzerland, March 31^st – April 4^th 2004

• Gold Cross for Merits of the Republic of Austria: “For medical and scientific merits”. One of the highest Distinction of the Republic of Austria, President of the Republic of Austria, Federal Ministry of Health, Vienna, Austria, June 30, 2006

• The Marie Curie Award. The Marie Curie Gold Medal with The Marie Curie Certificate in a golden coloured metal frame: ”for significant contributions to surgery”. Award presented at the Inaugural World Forum at Oxford University. Award Ceremony, Great Britain, July 4-9, 2006

• Founded Scientific Award "Gold Medal for Young Researcher in Cryosurgery". Made decision and vote of the Board of Directors. The 33^rd Annual Meeting of the Japan Society for Low Temperature Medicine. Tokyo, Japan, November 23-24, 2006

• SHUCHOV’s Gold Medal 2006 for the research and achievement in the field of Science and Technology Development. 150 Jubilees. Russian First Engineer and Great Inventor. Moscow, Russia, December 15, 2006

• State Medal of the Ukraine: “For Merits”. Distinction of the Ukraine, President of the Ukraine, Kyiv, Ukraine, December 22, 2006

• Award for Excellence in Cryosurgery. International Society of Cryosurgery, Beijing, China, November 2007

• Award of GOLD Medal. The Japan Society for Low Temperature Medicine, Tokyo, Japan, November 2009

• Grand Gold Medal. The highest distinction of the International Society of Cryosurgery. International Society of Cryosurgery, Vienna, Austria, November 2011

• Rudolf Virchov Medal "Detur digniori"
  European Academy of Natural Science, Hannover, Germany, June 2012

Please, for detail see: www.korpan.at

The science future begins in the first medicine lesson. In dissecting room (myself 2^nd from left). Chair of Anatomy, Morphological Building, Kyiv Medical Instiute. Kyiv, 11/1976

 

In the operating theatre. The first glimpse into the world of Cryoscience and Cryosurgery. The first cryosurgical unit and the first cryosurgical procedure by myself as a young doctor, surgeon and scientist. Department of General Surgery, Kyiv Medical Institute. Kyiv, 10/1982

 

Jordan University Hospital. Amman, Jordan, 1999

 

Al-Bashir Hospital. Amman, Jordan, 2000

 

The photos remind us of great memories… With Dr. Patrick J. Le Pivert (3^rd from right) and his Colleagues, Florida, USA in the operating theatre at the Vienna Hospital during cryosurgical operation by myself (2^nd from right). Vienna, Austria, 04/2000

 

Collegial and good-natured agreement with Dr. Patrick J. Le Pivert from the USA (left) about the scientific collaboration in the field of modern cryosurgery in the future. Operating theatre, Vienna, Austria, 04/2000

 

Operating Theatre. Baghdad, Iraq, 2001

 

Trip down memory lane: myself together with Prof. Dr. John Baust, USA, Prof. Dr. Andrew Gage, USA, and Prof. Dr. Sajio Sumida, Japan (from left to right). 39^th Meeting of the Society for Cryobiology. July 28^th–July 31^st, 2002, Breckenridge, USA

 

In the operating theater during cryosurgery for pancreas adenocarcinoma. Rudolfinerhaus, Vienna, 02/2005

 

Teaching on Modern Cryosurgery. Hanoi, Vietnam, 12/2007

 

Lecturing and training on modern cryoscience and cryosurgery with students from Germany. International Institute for Cryosurgery, Rudolfinerhaus. Vienna, 08/2008

 

Modern cryosurgery was successfully carried out in the patient with bleeding stenosed deep stump rectum adenocarcinoma by myself, assisted by Professor Dr. Lizhi NIU from Guangzhou, China (left) and Assistant Professor Dr. Franz SELLNER from the International Institute for Cryosurgery (right). Operating theatre at the Rudolfinerhaus Hospital, Vienna, Austria, April 11, 2011

 

Prof. Dr. Sajio SUMIDA, Japan, Prof. Dr. Nikolai N. KORPAN, Austria, and Prof. John G. BAUST, PhD, USA (from left)

International Seminar "CRYO 2012". International Institute for Cryosurgery, Rudolfinerhaus, Billroth Room & Lecture Hall, Vienna, Austria, October 14^th - 17^th, 2012

 

Gold Cross for Merits of the Republic of Austria: “For medical and scientific merits”. One of the highest Distinction of the Republic of Austria, President of the Republic of Austria, Federal Ministry of Health, Vienna, Austria, 06/2006

 

Selective References in Peer-Reviewed International Top-Journals & Books:

1. Korpan NN. Хирургическая тактика при непроходимости кишечника, обусловленной опухолевым процессом толстой кишки. Киев, 1981 (in Russian). [Surgical Strategy in Patients with Tumor Ileus, 1981].
   
2. Korpan NN. Криохирургия опухолей печени и поджелудочной железы. Харьков, 1984 (in Russian). [Cryosurgery for Liver  Tumor].
   
3. Korpan NN. Cryomethods in the General Surgery, 1984 (in Russian).
   
4. Korpan NN. External Hypothermia and Cryosurgery in the Treatment of Acute Pancreatitis, 1984 (in Russian).
   
5. Korpan NN. Низкие температуры в медицине. Киев, 1988 (in Russian). [Low Temperatures in Medicine].
   
6. Korpan NN. Гипотермия в неотложной брюшной хирургии. Киев, 1988 (in Russian). [Hypothermia in urgent abdominal surgery].
   
7. Korpan NN. Cryosurgery of Liver Metastases from Colorectal Cancer: Long-Term Follow-Up. Pre and Post Course Symposium. Colorectal Disease in 1996: An International Exchange of Medical and Surgical Concepts. February 5-23, Cleveland Clinic Florida, Florida, USA. 1996:21-23.
   
8. Korpan NN. Hepatic Cryosurgery for Liver Metastases. Long-Term Follow-Up. Ann Surg 1997; 225:193-201.
   
9. Korpan NN, ed. Atlas of Cryosurgery. Vol.1. Vienna: Springer Publisher, New York, Vienna, Sydney, Tokyo, Munich, 2001; 525p.
10. Korpan NN, ed. Basics of Cryosurgery. Vienna: Springer Publisher, New York, Vienna, Sydney, Tokyo, Munich, 2001; 325p.
    
11. Pekar R. and Korpan NN. Krebs: Die biologische und die medizinische Tragoedie. Bio-Onkologie. Publisher Wilhelm Maudrich Vienna-Monich-Bern, 2003; 266p.
    
12. Korpan NN. The ’Lunar Eclipse’ Phenomena in Living Nature. Low Temp Med, 2006; 32(4):72-77.
    
13. Korpan NN. A History of Cryosurgery: Its Development and Future. J Am Coll Surg 2007; 204:314-324.
    
14. Korpan NN. Cryosurgery: Ultrastructural Changes in Pancreas Tissue after Low Temperature Exposure. Technol Cancer Res Treat 2007; 6:59-67.
    
15. Korpan NN. Cryosurgery: Early Ultrastructural Changes in Liver Tissue in vivo. J Surg Res 2009; 1:54-65.
    
16. Korpan NN. Cryoscience and Cryomedicine: Deciphering of the Effect of Deep Low Temperatures on Living Matter. Low Temp Med 2009; 35(3):65-74.
    
17. Korpan NN. Cryoscience and Cryomedicine. From Fundamental Research to Clinical Implications. Vienna, University Facultas Publisher, 2009; 461p.
    
18. Korpan NN. Cryoscience and Cryomedicine. Lecture. Vienna, University Facultas Publisher, 2009; 217p.
    
19. Korpan NN. Modern Cryosurgery: Present and Future. In: Korpan NN and Sumida S, eds. 16^th World Congress of the ISC, Congress Book. Vienna, University Facultas Publisher, 2011; 29-30.
    
20. Korpan NN, Sellner F., Hochwarter G. Late Ultrastructural Mechanisms of Liver Tissue Injury. In: Korpan NN and Sumida S, eds. 16^th World Congress of the ISC, Congress Book. Vienna, University Facultas Publisher, 2011; 79-85.
21. Xu K, Korpan NN, Niu L, eds. Modern Cryosurgery for Cancer. World Scientific Publisher, Singapore – New Jersey – London – Beijing – Shanghai – Hong -Kong-Taipei-Chennai, 2012; 903p.

Remark: References 9 & 10 are called by the International Scientific and Medical Community as "Bible of Cryosurgery"

 

Selective National, European & International Patents:

USSR – 19

1.1. Patent No. 1135037, 1984
1.2. Patent No. 1215673, 1985
1.3. Patent No. 1286175, 1986
1.4. Patent No. 1362460, 1987
1.5. Patent No. 1572233, 1987
1.6. Patent No. 1442221, 1988
1.7. Patent No. 1447379, 1988
1.8. Patent No. 1454408, 1988
1.9. Patent No. 13966326, 1988
1.10. Patent No. 1450830, 1988
1.11. Patent No. 1428386, 1988
1.12. Patent No. 1507337, 1989
1.13. Patent No. 1543618, 1989
1.14. Patent No. 1519712, 1989
1.15. Patent No. 1487882, 1989
1.16. Patent No. 1621951, 1990
1.17. Patent No. 1607826, 1990
1.18. Patent No. 1573424, 1990
1.19. Patent No. 1672615, 1991

Austria – 14

2.1. Patenturkunde No. 409584, 2002
2.2. Patenturkunde No. 409715, 2002
2.3. Patenturkunde No. 409452, 2002
2.4. Patenturkunde No. 409818, 2002
2.5. Patenturkunde No. 409716, 2002
2.6. Patenturkunde No. 409585, 2002
2.7. Patenturkunde No. 409453, 2002
2.8. Patenturkunde No. 409454, 2002
2.9. Patenturkunde No. 410929, 2003
2.10. No. A 625/2003
2.11. No. A 1417/2003
2.12. No. A 1418/2003
2.13. No. A 1419/2003
2.14. No. A 1420/2003

World Patents – 17

3.1. European Union - 9
No.No. EP 1 076 528 B1 – EP 1 083 838 B1, 2002-2004 (Belgium, Switzerland, Liechtenstein, Cyprus, Germany, Denmark, Spain, Finland, France, Great Britain, Greece, Ireland, Italy, Luxemburg, Monaco, Netherlands, Portugal, Sweden)

3.2. USA - 5
3.2.1. No. US 6,468,269 B1, 2002
3.2.2. No. US 6,579,110 B2, 2003
3.2.3. No. US 6,565,556 B1, 2003
4.3.2.4. No. US 12/081,577B1, 2004
3.2.5. No. US 10/553,782B1 2006

3.3. Japan - 3
3.3.1. No. 561948, 2001
3.3.2. No. 562071, 2002
3.3.3. No. 562363, 2003

 

Extended Research Summary

Research: 1979 - at present

Lecture, Stockholm, 2009

Monographs

Video Channel on YouTube

Videos on SurgyTec.com (search Korpan)

 

 

isc.cryosurgery.at